Urinary cyclic adenosine monophosphate in young adults and elderly subjects. Issue 1 (January 1976)

• Record Type: Journal Article
• Authors: Gennari, C; Galli, M; Montagnani, M
• Is Part Of: Journal of clinical pathology. Volume 29:Issue 1(1976)
• Page Start: 69
• Page End: 72
• Publication Date: 1976-01
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.29.1.69
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : The 24-hour urinary excretion of cyclic 3', 5'-adenosine monophosphate (cAMP) was measured by a protein-binding assay in 55 healthy volunteers (aged 20-35 yr) and in 30 hospitalized elderly subjects (aged 70-93 yr). In the older subjects the mean 24-hour cAMP excretion was significantly lower; the correlation between cAMP excretion and age demonstrated a progressive decrease from the age of 70 to the tenth decade. Many different factors could account for the reduced urinary cAMP excretion in elderly subjects: a decline in the reactivity of the adenyl cyclase-cAMP system related to physiological ageing; reduced physical activity; a reduction in the glomerular filtration rate or decreased production of cAMP by tubular cells in the senile kidney.