Tranexamic acid therapy in ulcerative colitis. Issue 676 (February 1982)

• Record Type: Journal Article
• Authors: Hollanders, D.; Thomson, Jean M.; Schofield, Phillip F.
• Is Part Of: Postgraduate medical journal. Volume 58:Issue 676(1982)
• Page Start: 87
• Page End: 91
• Publication Date: 1982-02
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.58.676.87
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : The antifibrinolytic drug tranexamic acid was assessed in controlling bleeding in 12 patients with left-sided proctocolitis. The study was designed as a double-blind cross-over trial employing a dose of 4·5 g of tranexamic acid/day together with identical placebo. A statistically significant reduction in rectal bleeding was achieved in 50% of cases with a minimum of side effects. Sigmoidoscopic grading of rectal mucosal appearances was improved. Frequency of diarrhoea and stool consistency were not altered. Tranexamic acid may have a part to play in the management of selected patients with ulcerative colitis in whom bleeding is difficult to control with orthodox treatment.