Biochemical indices of response to hydroxychloroquine and sodium aurothiomalate in rheumatoid arthritis. Issue 5 (October 1981)

• Record Type: Journal Article
• Authors: Dixon, J S; Pickup, M E; Bird, H A; Lee, M R; Wright, V; Downie, W W
• Is Part Of: Annals of the rheumatic diseases. Volume 40:Issue 5(1981)
• Page Start: 480
• Page End: 488
• Publication Date: 1981-10
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.40.5.480
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Biochemical and clinical changes have been monitored in 30 patients with rheumatoid arthritis treated with either hydroxychloroquine or sodium aurothiomalate over a period of 6 months. Acute-phase reactants improved in both treatment groups, while serum sulphydryl and serum histidine improved only in the gold-treated patients. Correlation matrices were constructed from mean clinical and biochemical data at successive clinic visits. Correlations obtained with gold were more frequent and of a higher level of significance than those obtained with hydroxychloroquine at the doses we studied. This lends support to the use of correlation matrices as a screening test for potential long-term antirheumatoid activity of drugs in man.