Relation between soluble interleukin 2 receptor and clinical findings in patients with systemic lupus erythematosus. Issue 10 (October 1989)

• Record Type: Journal Article
• Authors: Tokano, Y; Murashima, A; Takasaki, Y; Hashimoto, H; Okumura, K; Hirose, S
• Is Part Of: Annals of the rheumatic diseases. Volume 48:Issue 10(1989)
• Page Start: 803
• Page End: 809
• Publication Date: 1989-10
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.48.10.803
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : The concentration of soluble interleukin 2 receptor (IL-2R) was determined in the serum of 54 patients with systemic lupus erythematosus (SLE) by an enzyme linked immunosorbent assay (ELISA) using two monoclonal antibodies with the IL-2R. Concentrations of soluble IL-2R in the serum of the patients with SLE (study group) were significantly higher than in 20 normal subjects (control group). The relation between concentrations of soluble IL-2R and clinical findings was investigated. The concentration of soluble IL-2R showed no particular relation with the clinical manifestations and did not correlate with the level of anti-DNA antibody or CH50. Significant correlation between the concentration of soluble IL-2R and disease activity did exist, however. Furthermore, the concentration of soluble IL-2R in some cases changed simultaneously with the disease activity. Thus the concentration of soluble IL-2R may serve as a new clinical indicator of disease activity in patients with SLE.