Measurement of the effects of a single dose of prazosin on the cerebral blood flow in hypertensive patients. Issue 662 (December 1980)

• Record Type: Journal Article
• Authors: Rutland, M. D.; Lee, T. Y.; Nimmon, C. C.; Granowska, M.; Britton, K. E.
• Is Part Of: Postgraduate medical journal. Volume 56:Issue 662(1980)
• Page Start: 818
• Page End: 822
• Publication Date: 1980-12
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.56.662.818
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : It was considered that the first dose reaction occurring with prazosin may have been due either to hypotension or to a specific reduction in cerebral blood flow. The development of a quantitative non-invasion nuclear medicine technique for cerebral flow has now made it possible to investigate the effects of prazosin on cerebral blood flow in hypertensive patients. This double-blind study showed a significant decrease in BP and a small just significant increase in cerebral blood flow following a single 1-mg dose of prazosin, when compared with a placebo. From these results, it is unlikely that the first dose reactions which occurred with prazosin were due to a specific reduction in cerebral blood flow.