Trisomy 8 restricted to cultured fibroblasts. Issue 3 (June 1976)

• Record Type: Journal Article
• Authors: Niss, R; Passarge, E
• Is Part Of: Journal of medical genetics. Volume 13:Issue 3(1976)
• Page Start: 229
• Page End: 234
• Publication Date: 1976-06
• Subjects: Medical genetics -- Periodicals; 616.042
• DOI: 10.1136/jmg.13.3.229
• Languages: English
• ISSNs: 1468-6244

Abstract

Abstract : In the course of re-examing cultured fibroblasts stored in liquid nitrogen from a patient with developmental retardation, solitary left kidney, and Wilms tumour, a cell line trisomic for chromosome 8 was found. Trisomy 8 was restricted to fibroblasts in the first 22 subcultures and was absent in later passages as well as in lymphocytes. A familial pericentric inversion of chromosome 2 was observed in three generations including the propositus but was though to be unrelated to the clinical problem. Multiple spontaneous chromosomal rearrangements were seen in several late subcultures.