Infection and interferon production in systemic juvenile chronic arthritis: a prospective study. Issue 1 (February 1984)

• Record Type: Journal Article
• Authors: de Vere-Tyndall, A; Bacon, T; Parry, R; Tyrrell, D A; Denman, A M; Ansell, B M
• Is Part Of: Annals of the rheumatic diseases. Volume 43:Issue 1(1984)
• Page Start: 1
• Page End: 7
• Publication Date: 1984-02
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.43.1.1
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Twenty-four episodes of disease exacerbation in 19 children suffering from systemic juvenile chronic arthritis were studied. Sixteen of these were preceded by an infection (chi 2 = 20.14, p less than 0.001), mostly of the upper respiratory tract. In the 10 cases seen during an infection causative agents were identified in 5 (herpes simplex, rhinovirus, and on 3 occasions streptococcus). The total number of infections was not increased when compared with infection rates predicted by several reported studies. In the absence of clinical infection, specific antibody titres to a panel of microbial antigens were similar to those of a control group but with a trend toward higher titres in patients with hypergammaglobulinaemia. Interferon (IFN) responses were not defective, though sequential in-vitro IFN production from peripheral blood mononuclear cells (PBM) fluctuated considerably in the same patients, occasionally being absent with no obvious clinical correlate. IFN-alpha was induced by stimulation with Newcastle disease virus (NDV), and the mean responses of the patients were significantly greater than those of controls. IFN-gamma production on phytohaemagglutinin (PHA) stimulation was similar in patients and control groups. IFN was not detected in any of the sera from patients or controls.