Effects of captopril in patients with chronic obstructive pulmonary disease and secondary pulmonary hypertension. Issue 749 (March 1988)

• Record Type: Journal Article
• Authors: Patakas, D.; Georgopoulos, D.; Rodini, H.; Christaki, P.
• Is Part Of: Postgraduate medical journal. Volume 64:Issue 749(1988)
• Page Start: 193
• Page End: 195
• Publication Date: 1988-03
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.64.749.193
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Ten patients with chronic obstructive pulmonary disease (COPD) with normal left ventricular function were given a single dose of captopril (0.25 mg/kg). Mean systemic arterial pressure, heart rate and coronary flow to the right ventricle were reduced significantly after captopril. In contrast captopril did not cause a significant fall in pulmonary arterial pressure or pulmonary vascular resistance. We conclude that captopril fails to produce haemodynamic benefits in such hypoxic patients and that angiotensin II is not playing a significant role in maintaining pulmonary vasoconstriction.