Clotrimazole in rheumatoid arthritis. Issue 5 (October 1980)

• Record Type: Journal Article
• Authors: Wojtulewski, J A; Gow, P J; Walter, J; Grahame, R; Gibson, T; Panayi, G S; Mason, J
• Is Part Of: Annals of the rheumatic diseases. Volume 39:Issue 5(1980)
• Page Start: 469
• Page End: 472
• Publication Date: 1980-10
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.39.5.469
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Forty-seven patients with active rheumatoid arthritis took part in an 8-week controlled study in which clotrimazole was compared with a standard nonsteroidal anti-inflammatory agent, ketoprofen. Although clotrimazole was shown to be effective in the treatment of the disease and superior to ketoprofen in certain measurements, if was also responsible for a high incidence of adverse effects. Improvement with clotrimazole took place more slowly but was more sustained than with ketoprofen. A significant rise in plasma cortisol and a fall in white cell count was observed in the clotrimazole treated patients.