Facile and greener hydrothermal honey‐based synthesis of Fe3O 4/Au core/shell nanoparticles for drug delivery applications. Issue 4 (28th October 2018)

• Record Type: Journal Article
• Authors: Rasouli, Elisa; Basirun, Wan Jeffrey; Johan, Mohd Rafie; Rezayi, Majid; Darroudi, Majid; Shameli, Kamyar; Shanavaz, Zohreh; Akbarzadeh, Omid; Izadiyan, Zahra
• Is Part Of: Journal of cellular biochemistry. Volume 120:Issue 4(2019)
• Page Start: 6624
• Page End: 6631
• Publication Date: 2018-10-28
• Subjects: Fe3O 4/Au core/shell nanoparticles -- green synthesis -- honey -- magnetic properties -- in vitro -- drug delivery -- MTT assay -- WEHI164 cells; Cytochemistry -- Periodicals; 572
• DOI: 10.1002/jcb.27958
• Languages: English
• ISSNs: 0730-2312

Abstract

Abstract: In the present research, we report a greener, faster, and low‐cost synthesis of gold‐coated iron oxide nanoparticles (Fe3 O4 /Au‐NPs) by different ratios (1:1, 2:1, and 3:1 molar ratio) of iron oxide and gold with natural honey (0.5% w/v) under hydrothermal conditions for 20 minutes. Honey was used as the reducing and stabilizing agent, respectively. The nanoparticles were characterized by X‐ray diffraction (XRD), UV‐visible spectroscopy, field emission scanning electron microscope (FESEM), energy‐dispersive X‐ray spectroscopy (EDXS), transmission electron microscopy (TEM), selected area electron diffraction (SAED), vibrating sample magnetometer (VSM), and fourier transformed infrared spectroscopy (FT‐IR). The XRD analysis indicated the presence of Fe3 O4 /Au‐NPs, while the TEM images showed the formation of Fe3 O4 /Au‐NPs with diameter range between 3.49 nm and 4.11 nm. The VSM study demonstrated that the magnetic properties were decreased in the Fe3 O4 /Au‐NPs compared with the Fe3 O4 ‐NPs. The cytotoxicity threshold of Fe3 O4 /Au‐NPs in the WEHI164 cells was determined by using the 3‐(4, 5‐dimethylthiazol‐2‐yl)‐2, 5‐diphenyltetrazolium bromide (MTT) assay. It was demonstrated no significant toxicity in higher concentration up to 140.0 ppm which can become the main candidates for biological and biomedical applications, such as drug delivery. Abstract : The cytotoxicity threshold of green synthesized Fe3O4/Au‐NPs in the WEHI164 cells was determined by using MTT assay. It was demonstrated no significant toxicity in higher concentration up to 140.0 ppm which can become the main candidates for biological and biomedical applications, such as drug delivery.