Immune subversion by HIV: part B. (8th December 2020)

• Record Type: Journal Article
• Authors: Vanpouille, Christophe; Margolis, Leonid
• Is Part Of: EMBO journal. Volume 39:Number 24(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-12-08
• Subjects: Molecular biology -- Periodicals; 572.805
• DOI: 10.15252/embj.2020107167
• Languages: English
• ISSNs: 0261-4189

Abstract

Abstract : While HIV‐1 infects T but not B cells, it nevertheless impairs the function of B cells and thereby contribute to the failure to produce neutralizing antibodies. In this issue, Kaw et al describe the mechanisms leading to this failure and report a key role for the HIV‐1 protein NEF in preventing B‐cell maturation into antibody‐producing plasma cells. Abstract : HIV‐1 evades the immune system through multiple strategies involving direct killing of infected CD4 T cells and suppression of B cell maturation to prevent the production of neutralizing antibodies.