Ankylosing spondylitis without B27: no evidence for gene conversion. Issue 12 (December 1988)

• Record Type: Journal Article
• Authors: Pease, C T; Ellis, S A; McMichael, A J; Brewerton, D A
• Is Part Of: Annals of the rheumatic diseases. Volume 47:Issue 12(1988)
• Page Start: 1001
• Page End: 1003
• Publication Date: 1988-12
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.47.12.1001
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Isoelectric focusing gel electrophoresis was used to look for variant HLA molecules in five patients with HLA-B27 negative ankylosing spondylitis (AS). The isoelectric points of the HLA-A and B antigens from these patients and HLA paired controls were identical. This implies that the HLA-A and B antigens from the patients with AS and the controls are similar. Gene conversion of a nucleotide sequence from a B27 positive gene is thus unlikely to be the explanation for the existence of AS in patients who are HLA-B27 negative by alloantisera typing.