Dissociated response related to corticosteroids in lung cancer treated by immunotherapy: A case report. Issue 5 (24th March 2021)

• Record Type: Journal Article
• Authors: Thomas, Quentin Dominique; Sinoquet, Léa; Maraver, Antonio; Quantin, Xavier
• Is Part Of: Clinical case reports. Volume 9:Issue 5(2021)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2021-03-24
• Subjects: case reports -- immunotherapy -- lung neoplasms -- programmed cell death 1 receptor -- tumor escape; Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.3973
• Languages: English
• ISSNs: 2050-0904

Abstract

Abstract: We report the case of a patient with a complete metastatic adrenal response on Pembrolizumab for metastatic lung cancer. Treatment with a systemic corticosteroid‐induced a time‐dependent progression at his metastatic site. Surprisingly, after stopping the corticosteroid, we observed a new complete response in long‐term adrenal metastases. Abstract : The administration of systemic corticosteroid therapy for a prolonged period in patients undergoing treatment with immune checkpoint inhibitors for metastatic lung cancer can have a direct impact on the tumor response and may be reversible.