High infiltration of CD20+ B lymphocytes in extranodal natural killer/T‐cell lymphoma is associated with better prognosis. (10th September 2020)

• Record Type: Journal Article
• Authors: Chen, Min‐Min; Zeng, Guo‐Peng; Li, Jing; Fu, Jun‐Hong; Long, Ya‐Yi; Pan, Jie‐Ying; Wei, Lin‐Zhi; Guan, Jie‐Ying; Lin, Ying‐Xi; You, Hua; Si, Cheng; Li, Wen‐Xing; Liang, Yi‐Jun; Liu, Da‐Hai; Liu, Fang; Liu, Fang
• Is Part Of: British journal of haematology. Volume 191:Number 5(2020)
• Page Start: e116
• Page End: e120
• Publication Date: 2020-09-10
• Subjects: CD20 -- B lymphocytes -- extranodal natural killer/T‐cell lymphoma (ENKTL) -- biomarker -- prognosis; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.17069
• Languages: English
• ISSNs: 0007-1048

Abstract

Abstract: Immune cells have an uncertain function during the progression of extranodal natural killer/T‐cell lymphoma (ENKTL). The present study determined the distribution, phenotype, and clinical significance of B lymphocytes in ENKTL. Immunohistochemistry indicated high infiltration of CD20 + B lymphocytes in the tumour tissues of 40% of the patients, and that a high infiltration correlated with better overall survival. Moreover, B lymphocytes had an active mature phenotype in situ and suppressed the proliferation of ENKTL cells in vitro . These results suggest that tumour infiltration of CD20 + B lymphocytes may be a new prognostic indicator for patients with ENKTL.