An evolutionary framework for treating pediatric sarcomas. Issue 11 (16th March 2020)

• Record Type: Journal Article
• Authors: Reed, Damon R.; Metts, Jonathan; Pressley, Mariyah; Fridley, Brooke L.; Hayashi, Masanori; Isakoff, Michael S.; Loeb, David M.; Makanji, Rikesh; Roberts, Ryan D.; Trucco, Matteo; Wagner, Lars M.; Alexandrow, Mark G.; Gatenby, Robert A.; Brown, Joel S.
• Is Part Of: Cancer. Volume 126:Issue 11(2020)
• Page Start: 2577
• Page End: 2587
• Publication Date: 2020-03-16
• Subjects: adaptive therapy -- clinical trial -- Ewing sarcoma -- evolution -- extinction therapy -- first strike -- osteosarcoma -- resistance -- rhabdomyosarcoma -- second strike; Cancer -- Periodicals; Cancer -- Cytopathology -- Periodicals; 616.99405
• DOI: 10.1002/cncr.32777
• Languages: English
• ISSNs: 0008-543X

Abstract

Abstract : Lessons from extinction can be used in trials designed to pursue a cure for cancer. When cancer cannot be cured, similar strategies may be unwise, and strategies that leverage the adaptations of cancer to therapy should be considered.