Selective removal of anti-double-stranded DNA antibodies by immunoadsorption with dextran sulphate in a patient with systemic lupus erythematosus. Issue 10 (October 1989)

• Record Type: Journal Article
• Authors: Kinoshita, M; Aotsuka, S; Funahashi, T; Tani, N; Yokohari, R
• Is Part Of: Annals of the rheumatic diseases. Volume 48:Issue 10(1989)
• Page Start: 856
• Page End: 860
• Publication Date: 1989-10
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.48.10.856
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : A dextran sulphate gel column removed anti-double-stranded DNA antibodies (anti-dsDNA) selectively, efficiently, and safely from the circulation of a patient with systemic lupus erythematosus (SLE). The mechanism of the removal is thought to be due to cross reactivity of anti-dsDNA with dextran sulphate, which has negatively charged units. Selective removal of anti-dsDNA is expected to contribute not only to the treatment but also to elucidation of the pathogenesis of SLE.