Cell-mediated immunity to myoglobin in polymyositis. Issue 2 (April 1983)

• Record Type: Journal Article
• Authors: Herrera-Esparza, R; Magaña, L; Moreno, J; Fraga, A; Lavalle, C
• Is Part Of: Annals of the rheumatic diseases. Volume 42:Issue 2(1983)
• Page Start: 182
• Page End: 186
• Publication Date: 1983-04
• Subjects: Rheumatism -- Periodicals; 616.723005
• DOI: 10.1136/ard.42.2.182
• Languages: English
• ISSNs: 0003-4967

Abstract

Abstract : Using the leucocyte migration inhibition (LIF) test we looked for evidence of cell-mediated hypersensitivity against myoglobin in 8 patients with polymyositis (PM) or dermatomyositis (DM). The migration index for PM-DM patients was 47.5 +/- 17%, while in the controls the index was 86 +/- 12% (p less than 0.001). The presence of serum antibodies against myoglobin was also investigated by passive haemagglutination (PH) and counterimmunoelectrophoresis (CIE). By PH the reciprocal titre of antimyoglobin antibodies was 150 +/- 28 in PM-DM compared with 16.2 +/- 15.9 and 8.7 +/- 7.7 in control patients with diseases (p less than 0.01) and negative in normal persons. CIE showed antimyoglobin antibodies in 3 PM-DM patients and in none of controls. Cell-mediated immunity against myoglobin may be implicated in the pathogenesis of PM. The pathological significance of antimyoglobin antibodies remains to be determined.