Cover Picture: Clickable Nucleic Acids: Sequence‐Controlled Periodic Copolymer/Oligomer Synthesis by Orthogonal Thiol‐X Reactions (Angew. Chem. Int. Ed. 48/2015). Issue 48 (16th October 2015)

• Record Type: Journal Article
• Authors: Xi, Weixian; Pattanayak, Sankha; Wang, Chen; Fairbanks, Benjamin; Gong, Tao; Wagner, Justine; Kloxin, Christopher J.; Bowman, Christopher N.
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 48(2015)
• Page Start: 14193
• Page End: 14193
• Publication Date: 2015-10-16
• Subjects: block copolymers -- click chemistry -- polymerization -- thiols; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201509369
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract : A click‐by‐click strategy that is based on orthogonal thiol‐X click reactions is used for the synthesis of nucleobase‐functionalized sequence‐controlled periodic polymer structures in a simple and efficient process. As demonstrated by C. N. Bowman and co‐workers in their Communication on page 14462 ff., this method enables the formation of highly functional materials, including a new class of synthetic oligonucleotides, in a robust, scalable manner.