An early experience on the effect of solid organ transplant status on hospitalized COVID‐19 patients. Issue 7 (13th January 2021)

• Record Type: Journal Article
• Authors: Nair, Vinay; Jandovitz, Nicholas; Hirsch, Jamie S.; Abate, Mersema; Satapathy, Sanjaya K.; Roth, Nitzan; Miyara, Santiago J.; Guevara, Sara; Kressel, Adam M.; Xiang, Alec; Wu, Grace; Butensky, Samuel D.; Lin, David; Williams, Stephanie; Bhaskaran, Madhu C.; Majure, David T.; Grodstein, Elliot; Lau, Lawrence; Nair, Gayatri; Fahmy, Ahmed E.; Winnick, Aaron; Breslin, Nadine; Berlinrut, Ilan; Molmenti, Christine; Becker, Lance B.; Malhotra, Prashant; Gautam‐Goyal, Pranisha; Lima, Brian; Maybaum, Simon; Shah, Samit K.; Takegawa, Ryosuke; Hayashida, Kei; Shinozaki, Koichiro; Teperman, Lewis W.; Molmenti, Ernesto P.;
• Other Names: Birabaharan Morgan investigator.; Bodenheimer Henry C. investigator.; Bolourani Siavash investigator.; Caruso Vincenza A. investigator.; Cohen Stuart L. investigator.; Dominello Andrew J. investigator.; Falzon Louise investigator.; Cookingham Jennifer investigator.; Johnson Jennifer C. investigator.; Minaya Josue investigator.; Keel Trey investigator.; Khatri Akshay investigator.; Koshy Robin V. investigator.; Kozel Zachary M. investigator.; Kvasnovsky Charlotte investigator.; Lesser Martin investigator.; Maria Naomi I. investigator.; Mogavero Jazmin N. investigator.; Monane Rachel investigator.; Najjar Salem investigator.; Ng Jia investigator.; Saif M. Wasif investigator.; Sheppard Acacia investigator.; Sison Cristina investigator.; Stevens Gerin R. investigator.; Tan Dylan investigator.; Vullaganti Sirish investigator.
• Is Part Of: American journal of transplantation. Volume 21:Issue 7(2021)
• Page Start: 2522
• Page End: 2531
• Publication Date: 2021-01-13
• Subjects: clinical research/practice -- immunosuppression/immune modulation -- infection and infectious agents ‐ viral -- infectious disease -- kidney (allograft) function/ dysfunction -- organ transplantation in general; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.16460
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : We compared the outcome of COVID‐19 in immunosuppressed solid organ transplant (SOT) patients to a transplant naïve population. In total, 10 356 adult hospital admissions for COVID‐19 from March 1, 2020 to April 27, 2020 were analyzed. Data were collected on demographics, baseline clinical conditions, medications, immunosuppression, and COVID‐19 course. Primary outcome was combined death or mechanical ventilation. We assessed the association between primary outcome and prognostic variables using bivariate and multivariate regression models. We also compared the primary endpoint in SOT patients to an age, gender, and comorbidity‐matched control group. Bivariate analysis found transplant status, age, gender, race/ethnicity, body mass index, diabetes, hypertension, cardiovascular disease, COPD, and GFR <60 mL/min/1.73 m 2 to be significant predictors of combined death or mechanical ventilation. After multivariate logistic regression analysis, SOT status had a trend toward significance (odds ratio [OR] 1.29; 95% CI 0.99–1.69, p = .06). Compared to an age, gender, and comorbidity‐matched control group, SOT patients had a higher combined risk of death or mechanical ventilation (OR 1.34; 95% CI 1.03–1.74, p = .027). Abstract : In an early experience from New York, hospitalized solid organ transplant recipients with COVID‐19 are more likely to reach a combined endpoint of death or mechanical ventilation than a large population of comorbidity‐matched controls.