Need for improvements in simultaneous heart‐kidney allocation: The limitation of pretransplant glomerular filtration rate. Issue 7 (9th February 2021)

• Record Type: Journal Article
• Authors: Shaw, Brian I.; Samoylova, Mariya L.; Sanoff, Scott; Barbas, Andrew S.; Sudan, Debra L.; Boulware, L. Ebony; McElroy, Lisa M.
• Is Part Of: American journal of transplantation. Volume 21:Issue 7(2021)
• Page Start: 2468
• Page End: 2478
• Publication Date: 2021-02-09
• Subjects: clinical research / practice -- donors and donation -- guidelines -- heart transplantation / cardiology -- kidney transplantation / nephrology -- organ procurement and allocation -- patient survival -- recipient selection -- Scientific Registry for Transplant Recipients (SRTR); Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.16466
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : The incidence of simultaneous heart‐kidney transplant (SHK) has increased markedly in the last 15 years. There are no universally agreed upon indications for SHK vs. heart alone (HA) transplant, and center evaluation processes vary widely. We utilized Scientific Registry of Transplant Recipients data from 2003 to 2017 to quantify changes in the practice of SHK, examine the survival of SHK vs. HA, and identify patients with marginal benefit from SHK. We used Kaplan–Meier curves and Cox proportional hazards to assess differences in survival. The incidence of SHK increased more than fourfold between 2003 and 2017 from 1.6% to 6.6% of total hearts transplanted, while the proportion of dialysis‐dependent patients undergoing SHK has remained constant. SHK was associated with increased survival in dialysis‐dependent patients (Median Survival SHK: 12.6 vs. HA: 7.1 years p < .0001) but not with nondialysis‐dependent patients (Median Survival SHK: 12.5 vs. HA 12.3, p = .24). The marginal effect of SHK in decreasing the hazard of death diminished with increasing eGFR. Delayed graft function occurred in 26% of SHK recipients. Posttransplant chronic dialysis was similar for both operations (6.4% of HA and 6.0% of SHK). Further study is needed to define patients who benefit from SHK. Abstract : National retrospective data demonstrates that the incidence of simultaneous heart‐kidney transplant is increasing, the association of simultaneous kidney transplant with survival among heart transplant recipients decreases with increasing kidney function, and a similar number of patients undergoing simultaneous kidney versus heart alone transplant progress to chronic dialysis after transplant.