The respiratory microbiome after lung transplantation: Reflection or driver of respiratory disease?. Issue 7 (16th April 2021)

• Record Type: Journal Article
• Authors: Eskind, Caroline C.; Shilts, Meghan H.; Shaver, Ciara M.; Das, Suman R.; Satyanarayana, Gowri
• Is Part Of: American journal of transplantation. Volume 21:Issue 7(2021)
• Page Start: 2333
• Page End: 2340
• Publication Date: 2021-04-16
• Subjects: infectious disease -- lung transplantation/pulmonology -- lung transplantation: living donor -- microbiome -- translational research/science; Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ajt.16568
• Languages: English
• ISSNs: 1600-6135

Abstract

Abstract : With the introduction of high‐throughput sequencing methods, our understanding of the human lower respiratory tract's inhabitants has expanded significantly in recent years. What is now termed the "lung microbiome" has been described for healthy patients, as well as people with chronic lung diseases and lung transplants. The lung microbiome of lung transplant recipients (LTRs) has proven to be unique compared with nontransplant patients, with characteristic findings associated with disease states, such as pneumonia, acute rejection, and graft failure. In this review, we summarize the current understanding of the lung microbiome in LTRs, not only focusing on bacteria but also highlighting key findings of the viral and the fungal community. Based on our knowledge of the lung microbiome in LTRs, we propose multiple opportunities for clinical use of the microbiome to improve outcomes in this population. Abstract : This review summarizes the current knowledge base of the lung microbiome, with particular focus on lung transplant patients, and considers future opportunities to utilize lung microbiome sequencing methods in the clinical care of lung transplant recipients.