Folding Up of Gold Nanoparticle Strings into Plasmonic Vesicles for Enhanced Photoacoustic Imaging. Issue 52 (11th November 2015)

• Record Type: Journal Article
• Authors: Liu, Yijing; He, Jie; Yang, Kuikun; Yi, Chenglin; Liu, Yi; Nie, Liming; Khashab, Niveen M.; Chen, Xiaoyuan; Nie, Zhihong
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 52(2015)
• Page Start: 15809
• Page End: 15812
• Publication Date: 2015-11-11
• Subjects: block copolymers -- gold nanoparticles -- photoacoustic imaging -- self‐assembly -- vesicles; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201508616
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: The stepwise self‐assembly of hollow plasmonic vesicles with vesicular membranes containing strings of gold nanoparticles (NPs) is reported. The formation of chain vesicles can be controlled by tuning the density of the polymer ligands on the surface of the gold NPs. The strong absorption of the chain vesicles in the near‐infrared (NIR) region leads to a much higher efficiency in photoacoustic (PA) imaging than for non‐chain vesicles. The chain vesicles were further employed for the encapsulation of drugs and the NIR light triggered release of payloads. This work not only offers a new platform for controlling the hierarchical self‐assembly of NPs, but also demonstrates that the physical properties of the materials can be tailored by controlling the spatial arrangement of NPs within assemblies to achieve a better performance in biomedical applications. Abstract : Chain vesicles : Hollow plasmonic vesicles were obtained by the folding up of gold nanoparticle strings. The strong absorption of the chain vesicles in the near‐infrared (NIR) region enables their application as contrast agents in photoacoustic imaging and as drug‐delivery vehicles with NIR light triggered drug release.