Cyclodextrin grafted calcium carbonate vaterite particles: efficient system for tailored release of hydrophobic anticancer or hormone drugs. Issue 106 (2nd November 2016)

• Record Type: Journal Article
• Authors: Lakkakula, Jaya R.; Kurapati, Rajendra; Tynga, Ivan; Abrahamse, Heidi; Raichur, Ashok M.; Maçedo Krause, Rui Werner
• Is Part Of: RSC advances. Volume 6:Issue 106(2016)
• Page Start: 104537
• Page End: 104548
• Publication Date: 2016-11-02
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra12951j
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : The porous cyclodextrin-CaCO3 microparticles are acting as the intelligent hydrophobic drug carriers, where the loaded drug is stable at blood pH but released at acidic pH (cancer cells) due to recrystallization of CaCO3 particles. Abstract : Porous CaCO3 microparticles have been used earlier for sustained drug release of hydrophilic drugs but have certain drawbacks for use with hydrophobic drugs. Hence, to overcome these drawbacks, a novel composite of CaCO3 along with cyclodextrin (CD–CaCO3 ) for the delivery of hydrophobic drugs was developed. Cyclodextrins (CDs), when incorporated within CaCO3, increased the porosity and surface area of microparticles thereby enhancing the encapsulation efficiency of hydrophobic drugs (5-Fluorouracil or Na-l -thyroxine) by forming inclusion complexes with cyclodextrin. Thermogravimetric and FTIR studies confirmed the interaction between the cyclodextrin and CaCO3 microparticles. Raman spectra confirmed the peak of vaterite crystals before and after loading of hydrophobic drugs within the composite. In vitro release studies when performed at pH 4.8 (5-Fu) and pH 1.2 (Na-l -thy) showed release at low pH as CaCO3 is soluble at acidic pH unlike slower release at basic pH. Release kinetics followed a Higuchi kinetic model at pH 4.8 (5-Fu) and pH 1.2 (Na-l -thy) respectively.