Development of a novel smartphone-based application for accurate and sensitive on-field hemoglobin measurement. Issue 106 (1st November 2016)

• Record Type: Journal Article
• Authors: Ghatpande, Niraj S.; Apte, Priti P.; Joshi, Bimba N.; Naik, Sadanand S.; Bodas, Dhananjay; Sande, Vishwajit; Uttarwar, Pravin; Kulkarni, Prasad P.
• Is Part Of: RSC advances. Volume 6:Issue 106(2016)
• Page Start: 104067
• Page End: 104072
• Publication Date: 2016-11-01
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c6ra24366e
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : A smartphone-based app for the accurate and sensitive measurement of hemoglobin was developed. Abstract : Here, we report on the development of a smartphone-based application (app) for the accurate and sensitive measurement of hemoglobin (Hb). Hb values obtained using the app correlated significantly ( R 2 = 0.976) with those obtained by an automated hematology analyzer. Bland–Altman analysis showed that the standard deviation of the difference between Hb measured by the two methods was 0.35 g dL −1 and the limits of agreement between the two methods were −0.62 to 0.75. A limit of detection of 0.66 g dL −1 was achieved using the app along with a 2 g dL −1 limit of quantification. Furthermore, measurement using the app was highly sensitive (94%) and specific (90%). The app was developed for a smartphone and it will be particularly useful in resource-limited conditions for the rapid, accurate, highly sensitive and specific assessment of anemia.