Lupus anticoagulant positivity in insulin dependent diabetic patients: an additional risk factor in the pathogenesis of diabetic retinopathy?. Issue 5 (1st May 2000)

• Record Type: Journal Article
• Authors: Giusti, Cristiano; Schiaffini, Riccardo; Bosco, Daniela; Ciampalini, Paolo; Pantaleo, Antonio; Vingolo, Enzo M; Gargiulo, Patrizia
• Is Part Of: British journal of ophthalmology. Volume 84:Issue 5(2000)
• Page Start: 531
• Page End: 533
• Publication Date: 2000-05-01
• Subjects: lupus anticoagulant positivity -- insulin dependent diabetes; Ophthalmology -- Periodicals; 617.7
• DOI: 10.1136/bjo.84.5.531
• Languages: English
• ISSNs: 0007-1161

Abstract

Abstract : AIMS: To investigate whether lupus anticoagulant (LA) positivity, a marker of endothelial dysfunction, might be relevant to the pathogenesis of diabetic retinopathy (DR). METHODS: 32 IDDM patients were examined for LA, fibrinogen, prothrombin (PT), PTT, prothrombin degradation products (F1+2), and activated protein C (APC). RESULTS: APC decreased and F1+2 increased significantly in LA positive but not in LA negative patients; 60% of LA positive and 18% of LA negative subjects had DR. PT, PTT, and fibrinogen levels were insignificant. CONCLUSION: These preliminary findings suggest that LA positivity could represent an additional risk factor for DR, acting as a link between the immunological and haemostatic systems.