Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study. Issue 8 (August 1989)

• Record Type: Journal Article
• Authors: Ochs, G; Struppler, A; Meyerson, B A; Linderoth, B; Gybels, J; Gardner, B P; Teddy, P; Jamous, A; Weinmann, P
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 52:Issue 8(1989)
• Page Start: 933
• Page End: 939
• Publication Date: 1989-08
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.52.8.933
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Twenty eight patients with severe, intractable spasticity have been treated by chronic intrathecal administration of baclofen. An implantable programmable drug-administration-device (DAD) was used with a permanent intrathecal catheter. Infusion of 50 to 800 micrograms/day of baclofen completely abolished spasticity. Follow-up was up to two years. Therapeutic effect was documented by clinical assessment of tone, spasms and reflexes and by electrophysiological recordings of mono- and polysynaptic reflex activity. Complications and untoward side-effects of the procedure were few. This procedure is recommended for spasticity of spinal origin refractory to physiotherapy and oral medication. It is a preferable alternative to ablative surgical intervention.