Comparative studies of a new commercial kit for the estimation of vitamin B12 in serum. Issue 9 (September 1981)

• Record Type: Journal Article
• Authors: Waters, H M; Thornton, J A; Stevens, R F; Gowenlock, A H; Maciver, J E; Delamore, I W
• Is Part Of: Journal of clinical pathology. Volume 34:Issue 9(1981)
• Page Start: 972
• Page End: 978
• Publication Date: 1981-09
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.34.9.972
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A commercial kit method (Technia Diagnostics) for the estimation of serum vitamin B12 claiming certain practical advantages was examined. Analytical and clinical performance were compared with a non-commercial radioisotope B12 method, previously compared to other commercial radioisotope B12 methods. The kit's analytical performance in our hands was satisfactory, although the within-batch precision and recovery of added cyanocobalamin were disappointing. Clinical performance was comparable with the non-commercial B12 method. Establishment of suitable reference ranges as a prerequisite to diagnostic use is apparent.