A Selective Release System Based on Dual‐Drug‐Loaded Mesoporous Silica for Nanoparticle‐Assisted Combination Therapy. Issue 25 (23rd May 2014)

• Record Type: Journal Article
• Authors: Wang, Wenqian; Wen, Yongqiang; Xu, Liping; Du, Hongwu; Zhou, Yabin; Zhang, Xueji
• Is Part Of: Chemistry. Volume 20:Issue 25(2014)
• Page Start: 7796
• Page End: 7802
• Publication Date: 2014-05-23
• Subjects: combination therapy -- drug delivery -- mesoporous materials -- nanotechnology -- selective release; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201402334
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: A selective release system was demonstrated with a dual‐cargo loaded MSNs. When stimulated by different signals (UV or H + ), this system could selectively release different kinds of cargoes individually. Furthermore, this system has been used to provide a combination of chemotherapy and biotherapy for cancer treatment. This controlled release system could be an important step in the development of more effective and sophisticated nanomedicine and nanodevices, due to the possibility of selective release of a complex multi‐drug. Abstract : Combined cargo combats cancer : A selective release system was demonstrated with dual‐cargo‐loaded mesoporous silica nanoparticles (MSNs). When stimulated by different signals (UV or H + ; see figure), this system could selectively release different kinds of cargoes in turn. In addition, this system has been used to provide a combination of chemotherapy and biotherapy for cancer treatment.