Nebulisation of surfactants in an animal model of neonatal respiratory distress. Issue 1 (1st January 1998)

• Record Type: Journal Article
• Authors: Fok, Tai Fai; Al-Essa, Mazen; Dolovich, Myrna; Rasid, Farid; Kirpalani, Haresh
• Is Part Of: Archives of disease in childhood. Volume 78:Issue 1(1998)
• Page Start: F3
• Page End: F9
• Publication Date: 1998-01-01
• Subjects: surfactant -- nebuliser -- respiratory distress syndrome -- rabbits; Infants -- Diseases -- Periodicals; Newborn infants -- Diseases -- Periodicals; Fetus -- Diseases -- Periodicals; 618.920105
• DOI: 10.1136/fn.78.1.F3
• Languages: English
• ISSNs: 1359-2998

Abstract

Abstract : AIMS: To evaluate pulmonary deposition and gas exchange following nebulisation of two surfactants by either a jet or an ultrasonic nebuliser. METHOD: After bronchoalveolar lavage (BAL), 19 rabbits were ventilated in four groups. Group A1 (n=5) and A2 (n=6) received Technetium-99m labelled Exosurf, and groups B1 (n=4) and B2 (n=4) received radiolabelled Survanta. Groups A1 and B1 received jet nebuliser therapy, whereas groups A2 and B2 received ultrasonic nebuliser. Pulmonary deposition, distribution, and blood gases were determined. RESULTS: Pulmonary deposition as per cent of initial dose and mg lipid) was 0.28(0.10)% or 0.59(0.21) mg in group A1, 1.05(0.23)% or 2.21(0.48) mg in group A2, 0.08(0.02)% or 0.30(0.08) mg in group B1, and 0.09(0.02)% or 0.34(0.08) mg in group B2. Deposition in group A2 was greater than in other groups (p= 0.001). Group A2 showed a small improvement in blood gases. CONCLUSIONS: Even the highest deposition—ultrasonic nebuliser witosurf—achieved limited clinical effect. The aerosol route is currently not effective for surfactant treatment.