Regulation of human gut B lymphocytes by T lymphocytes. Issue 1 (January 1984)

• Record Type: Journal Article
• Authors: Clancy, R; Cripps, A; Chipchase, H
• Is Part Of: Gut. Volume 25:Issue 1(1984)
• Page Start: 47
• Page End: 51
• Publication Date: 1984-01
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.25.1.47
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : The aims of this study were first, to assess whether or not immunoglobulin secretion from human gut mucosal B lymphocytes can be modified by T lymphocytes, and second whether human gut mucosal T lymphocytes are capable of regulating mucosal B lymphocyte function. T and B lymphocyte enriched cell populations were isolated from gut mucosa and co-cultured in varying proportions. Addition of T lymphocytes to B enriched mucosal cell populations (ratio B:T = 2:1) showed that mucosal B lymphocytes were responsive to T cell 'help'. Addition of more T cells (ratio B:T = 2:10) suppressed immunoglobulin synthesis.