Imerslund-Grasbeck syndrome in a Chinese family with distinct skin lesions refractory to vitamin B12. Issue 10 (October 1994)

• Record Type: Journal Article
• Authors: Lin, S H; Sourial, N A; Lu, K C; Hsueh, E J
• Is Part Of: Journal of clinical pathology. Volume 47:Issue 10(1994)
• Page Start: 956
• Page End: 958
• Publication Date: 1994-10
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.47.10.956
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Two brothers in a Chinese family with selective malabsorption of vitamin B12 associated with proteinuria (Imerslund-Grasbeck syndrome) presented with widespread mottled skin pigmentation, termed poikiloderma. In contrast to anaemia, this pigmentary disturbance remained unresponsive to vitamin B12 replacement. This is different from the reported hyperpigmentation sometimes seen in vitamin B12 deficiency which is reversible following treatment. As far as is known, an irreversible and persistent skin disorder has not been reported in this syndrome before.