Personalising sarcoma care using quantitative multimodality imaging for response assessment. Issue 4 (April 2021)

• Record Type: Journal Article
• Authors: Kalisvaart, G.M.; Bloem, J.L.; Bovée, J.V.M.G.; van de Sande, M.A.J.; Gelderblom, H.; van der Hage, J.A.; Hartgrink, H.H.; Krol, A.D.G.; de Geus-Oei, L.F.; Grootjans, W.
• Is Part Of: Clinical radiology. Volume 76:Issue 4(2021)
• Page Start: 313.e1
• Page End: 313.e13
• Publication Date: 2021-04
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2020.12.009
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : Over the last decades, technological developments in the field of radiology have resulted in a widespread use of imaging for personalising medicine in oncology, including patients with a sarcoma. New scanner hardware, imaging protocols, image reconstruction algorithms, radiotracers, and contrast media, enabled the assessment of the physical and biological properties of tumours associated with response to treatment. In this context, medical imaging has the potential to select sarcoma patients who do not benefit from (neo-)adjuvant treatment and facilitate treatment adaptation. Due to the biological heterogeneity in sarcomas, the challenge at hand is to acquire a practicable set of imaging features for specific sarcoma subtypes, allowing response assessment. This review provides a comprehensive overview of available clinical data on imaging-based response monitoring in sarcoma patients and future research directions. Eventually, it is expected that imaging-based response monitoring will help to achieve successful modification of (neo)adjuvant treatments and improve clinical care for these patients.