Defective suppression in the autologous mixed lymphocyte reaction in patients with Crohn's disease. Issue 6 (June 1989)

• Record Type: Journal Article
• Authors: Kelleher, D; Murphy, A; Whelan, C A; Feighery, C; Weir, D G; Keeling, P W
• Is Part Of: Gut. Volume 30:Issue 6(1989)
• Page Start: 839
• Page End: 844
• Publication Date: 1989-06
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.30.6.839
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : T helper and suppressor cell control of autologous immunoglobulin production was measured in 14 patients with Crohn's disease (CD) using autologous B cells or monocytes to stimulate regulatory T-cell activity. A pronounced defect in suppressor cell function was observed in the patient group but not in matched controls irrespective of whether B cells or monocytes were used as the stimulus. This defect was observed for IgG, A and M. This defect was seen both in patients with active disease and with inactive CD suggesting the possibility that a primary regulatory defect might exist in this disease. The patient group displayed normal helper cell function.