Increased myofibrillar protein catabolism in Duchenne muscular dystrophy measured by 3-methylhistidine excretion in the urine. Issue 10 (October 1977)

• Record Type: Journal Article
• Authors: McKeran, R O; Halliday, D; Purkiss, P
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 40:Issue 10(1977)
• Page Start: 979
• Page End: 981
• Publication Date: 1977-10
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.40.10.979
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Myofibrillar protein catabolic rate was calculated in seven patients with Duchenne muscular dystrophy from the amount of 3-methylhistidine excreted in the urine, and found to be over three times that found in a control series when expresses as the percentage of myofibrillar protein catabolised per day. It is suggested that measurement of myofibrillar protein catabolic rate may add a useful parameter in the study of muscle disorders.