Pyruvate kinase M2 (PKM2) in cancer and cancer therapeutics. (10th April 2021)

• Record Type: Journal Article
• Authors: Zhu, Susi; Guo, Yeye; Zhang, Xu; Liu, Hong; Yin, Mingzhu; Chen, Xiang; Peng, Cong
• Is Part Of: Cancer letters. Volume 503(2021)
• Page Start: 240
• Page End: 248
• Publication Date: 2021-04-10
• Subjects: Pyruvate kinase M2 -- Long noncoding RNA -- Tumor microenvironment -- Inhibitors -- Agonists; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2020.11.018
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: Pyruvate kinase M2 (PKM2), a key rate-limiting enzyme of glycolysis, is a critical regulator in tumor metabolism. PKM2 has been demonstrated to overexpressed in various cancers and promoted proliferation and metastasis of tumor cells. The errant expression of PKM2 has inspired people to investigate the function of PKM2 and the therapeutic potential in cancer. In addition, some studies have shown that the upregulation of PKM2 in tumor tissues is associated with the altered expression of lncRNAs and the poor survival. Therefore, researchers have begun to unravel the specific molecular mechanisms of lncRNA-mediated PKM2 expression in cancer metabolism. As the tumor microenvironment (TME) is essential in tumor development, it is necessary to identify the role of PKM2 in TME. In this review, we will introduce the role of PKM2 in different cancers as well as TME, and summarize the molecular mechanism of PKM2-related lncRNAs in cancer metabolism. We expect that this work will lead to a better understanding of the molecular mechanisms of PKM2 that may help in developing therapeutic strategies in clinic for researchers. Highlights: High expression of PKM2 in most tumors and plays the role of oncogenes. PKM2 participates in the regulation of tumor microenvironment and accelerates tumor progression. As the target gene of lncRNA, PKM2 participates in tumor regulation. In addition to inhibitors, PKM2 agonists can also inhibit the occurrence and development of tumors.