Catalytic Enantioselective Alkylation of Aldehydes by Using Organozinc Halide Reagents. Issue 10 (5th February 2013)

• Record Type: Journal Article
• Authors: Kinoshita, Yuichiro; Kanehira, Shinichi; Hayashi, Yasuki; Harada, Toshiro
• Is Part Of: Chemistry. Volume 19:Issue 10(2013)
• Page Start: 3311
• Page End: 3314
• Publication Date: 2013-02-05
• Subjects: alkylation -- asymmetric catalysis -- asymmetric synthesis -- organozinc reagents -- titanium; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201204346
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : Functionalized alkylzinc halides can be employed in the enantioselective addition to aldehydes by using a titanium(IV) catalyst derived from a H8 ‐binaphthol derivative in the presence of [Ti(O i Pr)4 ] and MgBr2 . A range of functionalities, including olefin, chlorine atoms, protected alcohols, amides, and cyano groups, are tolerated in the present reaction, providing the corresponding functionalized alcohols in high yields and enantioselectivities (see scheme).