Evaluation of health and environmental risks for juvenile tilapia (Oreochromis niloticus) exposed to florfenicol. Issue 12 (December 2020)

• Record Type: Journal Article
• Authors: Shiroma, Letícia Sayuri; Soares, Michelly Pereira; Cardoso, Israel Luz; Ishikawa, Marcia Mayumi; Jonsson, Claudio Martin; Nascimento Queiroz, Sonia Claudia
• Is Part Of: Heliyon. Volume 6:Issue 12(2020)
• Publication Date: 2020-12
• Subjects: Antibiotics -- Hematological variables -- Oxidative stress -- Aquaculture -- Agricultural water management -- Environmental science -- Environmental risk assessment -- Environmental toxicology -- Toxicology; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2020.e05716
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: Intensive fish cultivation has a high incidence of infection, which is often controlled by administering antibiotics. Florfenicol (FF) is one of the two antimicrobial drugs permitted for aquaculture in Brazil. Due to their intensive use, potentially harmful effects on aquatic organisms are of great concern. In this sense, we investigated whether the presence of FF in cultivation water could change the health parameters of Nile tilapia. For this, we evaluated hemoglobin, hematocrit, mean corpuscular hemoglobin (MCHC) concentration, mean corpuscular volume (MCV), total plasma protein (TPP), number of circulating red blood cells and leukocytes, as lipid peroxidation levels, catalase activity and glutathione S-transferase activity of fish exposed to 11.72 mg L −1 of FF in water for 48 h. The fish were divided into two groups: Nile tilapia in water with FF or without FF (control). Exposure to FF in cultivation water for a short period didn't change the hematological variables analyzed, but caused changes in liver ROS (Reactive oxygen species) markers of the Nile tilapia, which was revealed by lipid peroxidation levels, catalase activity, and glutathione S-transferase. The 48h exposure period was enough to induce oxidative stress in hepatocytes, causing cellular oxidative damage. Therefore, the antibiotic florfenicol may cause toxicity to organisms and aquatic ecosystems, even at a sublethal concentrations near 1/100 LC50-48h for fish species. Abstract : Antibiotics, Hematological Variables, Oxidative stress, Aquaculture; Agricultural Water Management; Environmental Science; Environmental Risk Assessment; Environmental Toxicology; Toxicology