Sulfadoxine specific lymphocyte transformation in a patient with eosinophilic pneumonia induced by sulfadoxine-pyrimethamine (Fansidar). Issue 4 (April 1989)

• Record Type: Journal Article
• Authors: Daniel, P T; Holzschuh, J; Berg, P A
• Is Part Of: Thorax. Volume 44:Issue 4(1989)
• Page Start: 307
• Page End: 309
• Publication Date: 1989-04
• Subjects: Chest -- Diseases -- Periodicals; Thorax; Chest -- Diseases; Periodicals; Periodicals; 617.54
• DOI: 10.1136/thx.44.4.307
• Languages: English
• ISSNs: 0040-6376

Abstract

Abstract : A patient developed eosinophilic peripheral pulmonary infiltrates while receiving malaria prophylaxis with sulfadoxine-pyrimethamine (Fansidar). Withdrawal of Fansidar and treatment with corticosteroids led to rapid recovery. No exacerbation occurred after cessation of corticosteroids. Lymphocyte transformation testing gave a positive result in the presence of sulfadoxine but not pyrimethamine. It is concluded that drug hypersensitivity to sulfadoxine was the cause of the eosinophilic pneumonia in this patient.