Changes in metabolism of cerebral glucose after stereotactic leukotomy for refractory obsessive-compulsive disorder: a case report. Issue 4 (April 1995)

• Record Type: Journal Article
• Authors: Biver, F; Goldman, S; François, A; De La Porte, C; Luxen, A; Gribomont, B; Lotstra, F
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 58:Issue 4(1995)
• Page Start: 502
• Page End: 505
• Publication Date: 1995-04
• Subjects: Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.58.4.502
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Brain glucose metabolism was investigated with PET and [18F]fluorodeoxyglucose, before and after a bifrontal stereotactic leukotomy in a 37 year old woman with refractory obsessive-compulsive disorder. A bilateral decrease in glucose metabolism was found in the orbital frontal cortex after psychosurgery. Glucose metabolism was decreased to a lesser degree in Brodmann's area 25, in the thalamus, and in the caudate nucleus. Clinical improvement in obsessive-compulsive disorder after stereotactic tractotomy seems to be associated with metabolic changes in the brain, in particular, in the orbital part of the frontal lobe.