A Glutathione‐Activated Phthalocyanine‐Based Photosensitizer for Photodynamic Therapy. Issue 21 (15th April 2014)

• Record Type: Journal Article
• Authors: He, Hui; Lo, Pui‐Chi; Ng, Dennis K. P.
• Is Part Of: Chemistry. Volume 20:Issue 21(2014)
• Page Start: 6201
• Page End: 6201
• Publication Date: 2014-04-15
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201400433
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract: Invited for the cover of this issue is the group of Dennis Ng at The Chinese University of Hong Kong. The image depicts the interaction of a molecular phthalocyanine‐quencher dyad with glutathione, resulting in detachment of the quencher, enhancement of fluorescence, and generation of singlet oxygen. The "activation" has also been demonstrated in tumor‐bearing nude mice. Read the full text of the article at 10.1002/chem.201400001 . Abstract : " The use of "smart" photosensitizers that can only be activated by tumor‐associated stimuli can confine the cytotoxic effect at the tumor and spare the normal tissues " Read more about the story behind the cover in the Cover Profile and about the research itself on page 6241 ff. (DOI: 10.1002/chem.201400001 ).