Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke. Issue 2 (1st August 2000)

• Record Type: Journal Article
• Authors: Werring, David J; Toosy, Ahmed T; Clark, Christopher A; Parker, Geoffrey JM; Barker, Gareth J; Miller, David H; Thompson, Alan J
• Is Part Of: Journal of neurology, neurosurgery and psychiatry. Volume 69:Issue 2(2000)
• Page Start: 269
• Page End: 272
• Publication Date: 2000-08-01
• Subjects: magnetic resonance imaging -- diffusion tensor -- stroke -- pathophysiology; Neurology -- Periodicals; Nervous system -- Surgery -- Periodicals; Psychiatry -- Periodicals; 616.8
• DOI: 10.1136/jnnp.69.2.269
• Languages: English
• ISSNs: 0022-3050

Abstract

Abstract : Diffusion tensor imaging (DTI) fully characterises water molecule mobility in vivo, allowing an exploration of fibre tract integrity and orientation in the human brain. Using DTI this study demonstrates reduced fibre coherence (anisotropy) associated with cerebral infarction and in the corticospinal tract remote from the lesion, in five patients 2 to 6 months after ischaemic stroke. The study highlights the potential of DTI to detect and monitor the structural degeneration of fibre pathways, which may provide a better understanding of the pattern of clinical evolution after stroke.