Oxpentifylline and cetiedil citrate improve deformability of dehydrated sickle cells. Issue 10 (October 1987)

• Record Type: Journal Article
• Authors: Stuart, J; Stone, P C; Bilto, Y Y; Keidan, A J
• Is Part Of: Journal of clinical pathology. Volume 40:Issue 10(1987)
• Page Start: 1182
• Page End: 1186
• Publication Date: 1987-10
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.40.10.1182
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : Erythrocytes from 14 patients with homozygous sickle cell anaemia were treated with the calcium ionophore A23187 to induce loss of cellular potassium and water. The dehydrated cells showed a decrease in filterability (loss of deformability) through pores of 5 micron diameter. Oxpentifylline and cetiedil citrate, which preserve erythrocyte cation and water content, had a significant (p less than 0.01) protective effect against loss of deformability at a concentration of 1 mumol/l. Oxpentifylline showed no adverse effect on the rheology, morphology, or haemolysis of sickle cells at concentrations up to 500 mumol/l. Drugs that act on the erythrocyte membrane to maintain cell hydration are of potential rheological benefit in sickle cell anaemia.