Ethanol in pancreatic juice after oral and intravenous administration. Issue 12 (December 1990)

• Record Type: Journal Article
• Authors: Gjørup, I; Dueholm, S; Andersen, B; Burcharth, F
• Is Part Of: Gut. Volume 31:Issue 12(1990)
• Page Start: 1411
• Page End: 1413
• Publication Date: 1990-12
• Subjects: Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.31.12.1411
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : Six patients with a drain in the main pancreatic duct were studied. Ethanol was given orally with individually adjusted doses aiming at a blood value of 0.8/1000 (17.6 mmol/l). Concentrations of ethanol in venous blood and pancreatic juice were recorded for three hours. Similar studies were made when ethanol was administered as an intravenous priming dose followed by a maintenance infusion. After orally administered ethanol, pancreatic juice values were higher than those in blood for a short period of time. The relations between median concentrations and time were incongruous curves consistent with a significant treatment by time interaction. Intravenous administration resulted in a similar pattern, but the interaction was not statistically significant. These findings indicate that the human pancreas may secrete ethanol.