Whole solid tumour volume histogram analysis of the apparent diffusion coefficient for differentiating high-grade from low-grade serous ovarian carcinoma: correlation with Ki-67 proliferation status. Issue 12 (December 2019)

• Record Type: Journal Article
• Authors: Li, H.M.; Zhang, R.; Gu, W.Y.; Zhao, S.H.; Lu, N.; Zhang, G.F.; Peng, W.J.; Qiang, J.W.
• Is Part Of: Clinical radiology. Volume 74:Issue 12(2019)
• Page Start: 918
• Page End: 925
• Publication Date: 2019-12
• Subjects: Medical radiology -- Periodicals; Radiotherapy -- Periodicals; Radiotherapy -- Periodicals; Radiology -- Periodicals; Societies, Medical -- Periodicals; Medical radiology; Radiotherapy; Electronic journals; Periodicals; 616.0757
• DOI: 10.1016/j.crad.2019.07.019
• Languages: English
• ISSNs: 0009-9260

Abstract

Abstract : AIM: To investigate whether apparent diffusion coefficient (ADC) histogram parameters based on whole solid tumour volume could differentiate high-grade (HGSOC) from low-grade serous ovarian carcinoma (LGSOC) and to correlate those parameters with the Ki-67 proliferation index. MATERIALS AND METHODS: One hundred and seven patients with HGSOCs and 19 patients with LGSOCs confirmed at surgery and histology who underwent conventional magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) were analysed retrospectively. ADC histogram parameters (including the mean, standard deviation [SD], 10th, 25th, 50th, 75th, and 90th percentiles, kurtosis, and skewness) were obtained using the whole solid tumour volume region of interest (ROI). The Mann–Whitney U test, Pearson's chi-square test, Fisher's exact test, kappa test, Spearman's correlation, and receiver operating characteristic (ROC) curves were used for statistical analyses. RESULTS: For ADC histogram parameters, the mean ( p< 0.001), SD ( p= 0.003), and all percentiles (10th, 25th, 50th, 75th, and 90th percentile; all p< 0.001) were significantly lower in HGSOC than in LGSOC, and the area under the ROC curve (AUC) was 0.717–0.807. Skewness was significantly higher in HGSOC than in LGSOC ( p< 0.001, AUC = 0.773); however, kurtosis was not significantly different between HGSOC and LGSOC ( p= 0.140). The 25th and 75th percentiles, SD and 10th percentile, and 75th percentile showed the highest sensitivity of 91.6%, specificity of 79.0%, and accuracy of 88.1%, respectively. All histogram parameters (except for kurtosis) were poorly correlated with the Ki-67 index (|r| = 0.191–0.274, p< 0.05). CONCLUSION: ADC histogram parameters based on whole solid tumour volume can be helpful for differentiating between HGSOC and LGSOC. Highlights: Most histogram metrics of ADC were significantly lower in HGSOC than in LGSOC. The 75th showed the highest sensitivity and accuracy of 91.6% and 88.1%, respectively. ADC histogram parameters showed a poor correlation with Ki-67 index.