Autoimmune hepatitis: a histological variant associated with prominent centrilobular necrosis. Issue 2 (1st August 1997)

• Record Type: Journal Article
• Authors: Te, H S; Koukoulis, G; Ganger, D R
• Is Part Of: Gut. Volume 41:Issue 2(1997)
• Page Start: 269
• Page End: 271
• Publication Date: 1997-08-01
• Subjects: autoimmunity -- hepatitis -- chronic active hepatitis -- histology; Gastroenterology -- Periodicals; 616.33
• DOI: 10.1136/gut.41.2.269
• Languages: English
• ISSNs: 0017-5749

Abstract

Abstract : A patient presented with pruritus and recent elevation of aminotransferases. The case fulfilled most of the criteria for the diagnosis of autoimmune hepatitis and achieved clinical and complete biochemical response to steroid therapy. However, the liver biopsy specimen revealed an unusual histological pattern consisting of severe centrilobular necrosis demarcated by a thin rim of hepatitic reaction. In contrast, the portal tracts appeared almost normal. This histological appearance has not been associated with autoimmune hepatitis. This presentation and the histology may represent an early pattern of autoimmune injury to the liver.