Combination antifungal therapy for cryptococcal meningitis. Issue 607 (May 1976)

• Record Type: Journal Article
• Authors: Tobias, J. S.; Wrigley, P. F. M.; Shaw, Elizabeth
• Is Part Of: Postgraduate medical journal. Volume 52:Issue 607(1976)
• Page Start: 305
• Page End: 308
• Publication Date: 1976-05
• Subjects: Medicine -- Periodicals; 610
• DOI: 10.1136/pgmj.52.607.305
• Languages: English
• ISSNs: 0032-5473

Abstract

Abstract : Two patients with Hodgkin's disease and cryptococcal meningitis are described. Both patients were treated with a combination of the two antifungal agents, amphotericin B and flucytosine. Nephrotoxicity was easily reversible in both patients and clinical improvement was seen with this combination therapy. Intrathecal therapy with amphotericin B was used in both patients. The optimal treatment of this disease may prove to be a combination of oral flucytosine, with amphotericin B given by intrathecal injection as well as rapid low dose intravenous injection.