Nicorandil abolished repolarisation alternans in a patient with idiopathic long QT syndrome. Issue 5 (1st November 1999)

• Record Type: Journal Article
• Authors: Fujimoto, Y; Morita, H; Fukushima, K K; Ohe, T
• Is Part Of: Heart. Volume 82:Issue 5(1999)
• Page Start: e8
• Page End: e8
• Publication Date: 1999-11-01
• Subjects: long QT syndrome -- repolarisation alternans -- nicorandil -- potassium channels; Heart -- Diseases -- Treatment -- Periodicals; Cardiology -- Periodicals; 616.12
• DOI: 10.1136/hrt.82.5.e8
• Languages: English
• ISSNs: 1355-6037

Abstract

Abstract : A 23 year old woman with idiopathic long QT syndrome had repeated syncopal attacks associated with torsades de pointes. T wave alternans (TWA) was recorded and the QT interval was abnormally prolonged during treadmill exercise test. Monophasic action potential (MAP) alternans also appeared after an abrupt shortening of the cycle length in electrophysiological study. After intravenous administration of nicorandil 6 mg, both TWA and MAP alternans disappeared.