A postsynthetic ion exchange method for tunable doping of hydroxyapatite nanocrystals. Issue 89 (15th December 2017)

• Record Type: Journal Article
• Authors: Chen, Gaoyu; Zheng, Xiaoyan; Wang, Chong; Hui, Junfeng; Sheng, Xuexi; Xu, Xiangxing; Bao, Jianchun; Xiu, Weijun; Yuwen, Lihui; Fan, Daidi
• Is Part Of: RSC advances. Volume 7:Issue 89(2017)
• Page Start: 56537
• Page End: 56542
• Publication Date: 2017-12-15
• Subjects: Chemistry -- Periodicals; 540.5
• DOI: 10.1039/c7ra10516a
• Languages: English
• ISSNs: 2046-2069

Abstract

Abstract : Hydroxyapatite nanocrystals were doped with various metal ions with tunable doping level and preserved morphology via a postsynthetic approach. Abstract : Hydroxyapatite (HAp) is the main inorganic component of human bones and teeth. The doping of HAp nanocrystals plays an important role in tissue engineering, drug delivery, biomarkers and artificial bones. In this article, a postsynthetic metal ion exchange method was developed for doping hydroxyapatite (HAp) nanocrystals in organic solutions. It can be mono- or multi-ion doped with Mg 2+, Sr 2+, Zn 2+, Mn 2+, Fe 3+ or Cu 2+ etc., despite the significant radius variation of Ca 2+ and doping ions. The doping ratio can be tuned in a wide range, e.g. Fe 3+ of 0–20%, which is much higher than the ion exchange performed in aqueous solution. The structure and morphology of the HAp nanocrystals were preserved after postsynthetic doping, suggesting potential biological applications.