Hypothesis: when is a seminoma not a seminoma?. Issue 2 (February 1981)

• Record Type: Journal Article
• Authors: Raghavan, D; Heyderman, E; Monaghan, P; Gibbs, J; Ruoslahti, E; Peckham, M J; Neville, A M
• Is Part Of: Journal of clinical pathology. Volume 34:Issue 2(1981)
• Page Start: 123
• Page End: 128
• Publication Date: 1981-02
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.34.2.123
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : A xenograft line, HX 53, has been established in immune-suppressed mice from a specimen of a lymph node metastasis in a patient with a histological diagnosis of seminoma but with markedly raised circulating levels of alpha-fetoprotein. Histological, immunocytochemical, and ultrastructural studies of this xenograft line have suggested that a solid variant of yolk sac carcinoma may exist, which morphologically resembles seminoma, or that a continuum of differentiation exists between seminoma and yolk sac carcinoma.