Reactogenicity and immunogenicity of a surface-antigen-adsorbed influenza virus vaccine in children. Issue 6 (June 1979)

• Record Type: Journal Article
• Authors: Eastwood, L M; Jennings, R; Milner, R D; Potter, C W
• Is Part Of: Journal of clinical pathology. Volume 32:Issue 6(1979)
• Page Start: 534
• Page End: 537
• Publication Date: 1979-06
• Subjects: Pathology -- Periodicals; Pathology, Molecular -- Periodicals; 616.0705
• DOI: 10.1136/jcp.32.6.534
• Languages: English
• ISSNs: 0021-9746

Abstract

Abstract : An influenza virus vaccine containing the purified surface haemagglutinin and neuraminidase antigens of A/Victoria/75 and B/Hong Kong/73 viruses adsorbed to an aluminium hydroxide gel was assessed for reactogenicity and immunogenicity in children aged 4 to 11 years, since there is no influenza virus vaccine available for this age group. Significant serum haemagglutination-inhibiting antibody responses to the A/Victoria/75 and B/Hong Kong/73 haemagglutinin antigens present in the vaccine were observed in 47% and 35%, respectively, of the children vaccinated, with a single dose. The vaccine induced no significant local or systemic reactions.